Xavier Cheng-Hong Tsai

Xavier Cheng-Hong Tsai

Assistant Professor and Attending Physician at National Taiwan University Hospital

Publications

You can also find my articles on my Google Scholar profile

2024

  • Tien FM, Yao CH, Tsai CH, Lo MY, Chen CY, Lee WH, Lin CC, Kuo YY, Peng YL, Tseng MH, Wu YS, Liu MC, Lin LI, Chuang MK, Ko BS, Yao M, Tang JL, Chou WC, Hou HA, Tien HF. Dysregulated immune and metabolic pathways are associated with poor survival in adult acute myeloid leukemia with CEBPA bZIP in-frame mutations. Blood Cancer J . 2024 Jan 23;14(1):15. [Pubmed]

2023

  • Fleming SA, Tsai CH (co-first author), Morris R, Hou HA, Wei A. TP53 status and impact on AML prognosis within the ELN 2022 risk classification. Blood. 2023 Dec 7;142(23):2029-2033 [Pubmed]
  • Lee WH, Lin CC, Wang YH, Yao CY, Kuo YY, Tseng MH, Peng YL, Hsu CA, Sun HI, Chuang YK, Hsu CL, Tien FM, Tsai CH, Chou WC, Hou HA, Tien HF. Distinct genetic landscapes and their clinical implications in younger and older patients with myelodysplastic syndromes. Hematol Oncol. 2023 Aug;41(3):463 [Pubmed]
  • Lo MY, Tsai CH, Lin CC, Tien FM, Kuo YY, Lee WH, Peng YL, Liu MC, Tseng MH, Hsu CA, Chen JE, Lin LI, Sun HI, Chuang YK, Ko BS, Tang JL, Yao M, Chou WC, Hou HA, Tien HF. Validation of the prognostic significance of the 2022 European LeukemiaNet risk stratification system in intensive chemotherapy treated aged 18 to 65 years patients with de novo acute myeloid leukemia. Am J Hematol. 2023 May;98(5):760 [Pubmed]
  • Cheng CL, Yao CY, Huang PH, Yu CW, Fang WQ, Chuang WH, Wu SJ, Lin YJ, Hung YC, Tsai CH, Yu SC, Chou WC, Tien HF. Cerebrospinal fluid soluble programmed death-ligand 1 is a useful prognostic biomarker in primary central nervous system lymphoma. Br J Haematol. 2023 Apr;201(1):75 [Pubmed]
  • Song YQ, Herve Tilly, Shinya Rai, Zhang HL, Jin Jie, Hideki Goto, Yasuhito Terui, Shin HJ, Kim WS, Cao JN, Feng JF, Hyeon-Seok Eom, Tae Min Kim, Tsai CH, Gau JP, Hideo Koh, Zhang LL, Song YP, Yang Y, Li W, Huang H, Kiyoshi Ando, Jeff P Sharman, Laurie H Sehn, Lilian Bu, Wang X, Jian YW, Jamie Hirata, Calvin Lee, Jun Zhu, Koji Izutsu. Polatuzumab vedotin in previously untreated DLBCL: an Asia subpopulation analysis from the Phase 3 POLARIX trial. Blood. 2023 Apr 20;141(16):1971 [Pubmed]
  • Cheng CL, Yeh PT, Fang WQ, Ma WL, Hou HA, Tsai CH, Lin CP, Tien HF. Long-term outcomes of combined intravitreal methotrexate and systemic high-dose methotrexate therapy in vitreoretinal lymphoma. Cancer Med. 2023 Apr;12(7):8102 [Pubmed]
  • Lee WH, Lin CC, Tsai CH, Tien FM, Lo MY, Ni SC, Yao M, Tseng MH, Liu MC, Tang JL, Sun HI, Chuang YK, Chou WC, Hou HA, Tien HF. Clinico-genetic and prognostic analyses of 716 patients with primary MDS and MDS/AML based on the 2022 International Consensus Classification. Am J Hematol. 2023 Mar;98(3):398 [Pubmed]
  • Tsai CH, Sun KJ, Lo MY, Tien FM, Kuo YY, Tseng MH, Peng YL, Chuang YK, Ko BS, Tang JL, Sun HI, Liu MC, Liu CW, Lin CC, Yao M, Chou WC, Hou HA, Tien HF. Poor prognostic implications of myelodysplasia-related mutations in both older and younger patients with de novo AML. Blood Cancer J. 2023 Jan 4;13(1):4 [Pubmed]

2022

  • Lee WH, Lin CC, Tsai CH, Tseng MH, Kuo YY, Liu MC, Tang JL, Sun HI, Chuang YK, Chou WC, Hou HA, Tien HF. Effect of mutation allele frequency on the risk stratification of myelodysplastic syndrome patients. Am J Hematol. 2022 Dec;97(12):1589. [Pubmed]
  • Lee WH, Lin CC, Wang YH, Yao CY, Kuo YY, Tseng MH, Peng YL, Hsu CA, Sun HI, Chuang YK, Hsu CL, Tien FM, Tsai CH, Chou WC, Hou HA, Tien HF. Distinct genetic landscapes and their clinical implications in younger and older patients with myelodysplastic syndromes. Hematol Oncol. 2022 Nov 24. [Pubmed]
  • Wang YH, Yao CY, Lin CC, Chen CL, Hsu CL, Tsai CH, Hou HA, Chou WC, Tien HF. Higher RUNX1 expression levels are associated with worse overall and leukaemia-free survival in myelodysplastic syndrome patients. EJHaem. 2022 Aug 19;3(4):1209. [Pubmed]
  • Huang CW, Tsai CH, Lin CW. Optic neuropathy after chimeric antigen receptor T-cell therapy. J Formos Med Assoc. 2022 May;121(5):1012. [Pubmed]
  • Wang YH, Tien FM, Tsai CH, Huang HH, Liu JH, Liao XW, Tang JL, Yao M, Ko BS. Busulfan-containing conditioning regimens in allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia: A Taiwan observational study. Cancer Rep (Hoboken). 2022 Mar;5(3):e1488. [Pubmed]
  • Tsai CH, Chen TT, Gau JP, Wang PN, Liu YC, Lien MY, Li CC, Yao M, Ko BS. Outcomes of Different Haploidentical Transplantation Strategies from the Taiwan Blood and Marrow Transplantation Registry. Cancers (Basel). 2022 Feb 21;14(4):1097. [Pubmed]
  • Wang YW, Tsai CH, Hou HA, Tien FM, Liu JH, Chou WC, Ko BS, Chen YW, Lin CC, Cheng CL, Lo MY, Lin YC, Lu LC, Wu SJ, Kuo SH, Hong RL, Huang TC, Yao M. Polatuzumab Vedotin-based Salvage Immunochemotherapy as Third-line or Beyond Treatment for Patients with Diffuse Large B-cell Lymphoma: a Real World Experience. Ann Hematol. 2022 Feb;101(2):349. (Corresponding author). [Pubmed]
  • Wang YH, Lin CC, Yao CY, Hsu CL, Tsai CH, Hou HA, Chou WC, Tien HF. Immune signatures of bone marrow cells can independently predict prognosis in patients with myelodysplastic syndrome. Br J Haematol. 2022 Jan;196(1):156-168. [Pubmed]
  • Lee SH, Lin CC, Wei CH, Chang KP, Yuan CT, Tsai CH, Liu JH, Hou HA, Tang JL, Chou WC, Tien HF. PD‐L1 expression in megakaryocytes and its clinicopathological features in primary myelofibrosis patients. J Pathol Clin Res. 2022 Jan;8(1):78-87. [Pubmed]
  • Tien FM, Tsai CH, Huang SC, Liu JH, Chen CY, Kuo YY, Chuang YK, Tseng MH, Peng YL, Liu MC, Liu CW, Liao XW, Lin LI, Wu YS, Hou MF, Wu SJ, Hsu SC, Ko * BS, Chou WC, Yao M, Hou HA, Tang JL, Tien HF. Distinct clinico-biological features in AML patients with low allelic ratio FLT3-ITD: role of allogeneic stem cell transplantation in first remission. Bone Marrow Transplant. 2022 Jan;57(1):95. [Pubmed]

2021

  • Wang YH, Hou HA, Lin CC, Kuo YY, Yao CY, Hsu CL, Tseng MH, Tsai CH, Peng YL, Kao CJ, Chou WC, Tien HF. A CIBERSORTx-based immune cell scoring system could independently predict the prognosis of patients with myelodysplastic syndromes. Blood Adv. 2021 Nov 23;5(22):4535-4548. [Pubmed]
  • Tsai CH, Tang JL, Tien FM, Kuo YY, Wu DC, Lin CC, Tseng MH, Peng YL, Hou MF, Chuang YK, Liu MC, Liu CW, Yao M, Lin LI, Chou WC, Chen CY, Hou HA, Tien HF. Clinical implications of sequential MRD monitoring by NGS at 2 time points after chemotherapy in patients with AML. Blood Adv. 2021 May 25;5(10):2456-2466. [Pubmed]
  • Wang WH, Lu MY, Tsai CH, Wang SC, Chou SW, Jou ST. A child with juvenile myelomonocytic leukemia possessing a concurrent germline CBL mutation and a NF1 variant of uncertain significance: A rare case with a common problem in the era of high-throughput sequencing. J Formos Med Assoc. 2021 Apr;120(4):1148-1152. [Pubmed]
  • Wang YH, Lin CC, Hsu CL, Hung SY, Yao CY, Lee SH, Tsai CH, Hou HA, Chou WC, Tien HF. Distinct clinical and biological characteristics of acute myeloid leukemia with higher expression of long noncoding RNA KIAA0125. Ann Hematol. 2021 Feb;100(2):487-498. [Pubmed]
  • Hung SY, Lin CC, Hsu CL, Yao CY, Wang YH, Tsai CH, Hou HA, Chou WC, Tien HF. The expression levels of long non‐coding RNA KIAA0125 are associated with distinct clinical and biological features in myelodysplastic syndromes. Br J Haematol. 2021 Feb;192(3):589-598. [Pubmed]

2020

  • Wang YW, Tsai CH, Lin CC, Tien FM, Chen YW, Lin HY, Yao M, Lin YC, Lin CT, Cheng CL, Tang JL, Chou WC, Hou HA, Tien HF. Cytogenetics and mutations could predict outcome in relapsed and refractory acute myeloid leukemia patients receiving BCL-2 inhibitor venetoclax. Ann Hematol. 2020 Mar;99(3):501-511.[Pubmed]
  • Wang YH, Lin CC, Lee SH, Tsai CH, Wu SJ, Hou HA, Huang TC, Kuo YY, Yao M, Chang KP, Lin CW, Lin YC, Tien FM, Chou WC, Tang JL, Tien HF. ASXL1 mutation confers poor prognosis in primary myelofibrosis patients with low JAK2V617F allele burden but not in those with high allele burden. Blood Cancer J. 2020 Oct 12;10(10):99.[Pubmed]
  • Wang YH, Lin CC, Yao CY, Hsu CL, Hou HA, Tsai CH, Chou WC, Tien HF. A 4-gene leukemic stem cell score can independently predict the prognosis of myelodysplastic syndrome patients. Blood Adv. 2020 Feb 25;4(4):644-654.[Pubmed]

2019

  • Tien FM, Tsai CH, Liu JH, Lin CT. Brentuximab vedotin as a salvage treatment for relapsed and refractory Hodgkin lymphoma patients in Taiwan. J Formos Med Assoc. 2019 Oct;118(10):1466-1470 (Corresponding author) [Pubmed]
  • Liu JH, Liao XW, Chen CH, Yao M, Li CC, Lin CT, Tsai CH, Chou WC, Hou HA, Huang SY, Wu SJ, Chen YC, Tien HF, Tang JL, Ko BS. Adoptive donor immunity protects against resolved hepatitis B virus reactivation after allogeneic haematopoietic stem cell transplantation in the world’s largest retrospective cohort study. Br J Haematol. 2019 Jul;186(1):72-85 [Pubmed]
  • Tsai CH, Yao CY, Tien FM, Tang JL, Kuo YY, Chiu YC, Lin CC, Tseng MH, Peng YL, Liu MC, Liu CW, Yao M, Lin LI, Chou WC, Chen CY, Hou HA, Tien HF. Incorporation of long non-coding RNA expression profile in the 2017 ELN risk classification can improve prognostic prediction of acute myeloid leukemia patients. EBioMedicine. 2019 Feb;40:240-250 [Pubmed]

2018

  • Ko BS, Wang YF, Li JL, Li CC, Weng PF, Hsu SC, Hou HA, Huang HH, Yao M, Lin CT, Liu JH, Tsai CH, Huang TC, Wu SJ, Huang SY, Chou WC, Tien HF, Lee CC, Tang JL. Clinically validated machine learning algorithm for detecting residual diseases with multicolor flow cytometry analysis in acute myeloid leukemia and myelodysplastic syndrome. EBioMedicine. 2018 Nov;37:91-100 [Pubmed]
  • Tien FM, Hou HA, Tang JL, Kuo YY, Chen CY, Tsai CH, Yao M, Lin CT, Li CC, Huang SY, Ko BS, Hsu SC, Wu SJ, Liu JH, Chou SC, Tsay W, Tseng MH, Liu MC, Liu CW, Lin LI, Chou WC, Tien HF. Concomitant WT1 mutations predict poor prognosis in acute myeloid leukemia patients with double mutant CEBPA. Haematologica. 2018 Nov;103(11):e510-e513 [Pubmed]
  • Tefferi A, Gangat N, Mudireddy M, Lasho TL, Finke C, Begna KH, Elliott MA, Al-Kali A, Litzow MR, Hook CC, Wolanskyj AP, Hogan WJ, Patnaik MM, Pardanani A, Zblewski DL, He R, Viswanatha D, Hanson CA, Ketterling RP, Tang JL, Chou WC, Lin CC, Tsai CH, Tien HF, Hou HA. Mayo Alliance Prognostic Model for Myelodysplastic Syndromes: Integration of Genetic and Clinical Information. Mayo Clin Proc. 2018 Oct;93(10):1363-1374 [Pubmed]
  • Tien FM, Hou HA, Tsai CH, Tang JL, Chiu YC, Chen CY, Kuo YY, Tseng MH, Peng YL, Liu MC, Liu CW, Liao XW, Lin LI, Lin CT, Wu SJ, Ko BS, Hsu SC, Huang SY, Yao M, Chou WC, Tien HF. GATA2 zinc finger 1 mutations are associated with distinct clinico-biological features and outcomes different from GATA2 zinc finger 2 mutations in adult acute myeloid leukemia. Blood Cancer J. 2018 Aug 31;8(9):87 [Pubmed]
  • Yang YT, Chiu YC, Kao CJ, Hou HA, Lin CC, Tsai CH, Tseng MH, Chou WC, Tien HF. The prognostic significance of global aberrant alternative splicing in patients with myelodysplastic syndrome. Blood Cancer J. 2018 Aug 13;8(8):78 [Pubmed]
  • Tien FM, Hou HA, Tsai CH, Tang JL, Chen CY, Kuo YY, Li CC, Lin CT, Yao M, Huang SY, Ko BS, Hsu SC, Wu SJ, Tsay W, Tseng MH, Liu MC, Liu CW, Lin LI, Chou WC, Tien HF. Hyperleukocytosis is associated with distinct genetic alterations and is an independent poor-risk factor in de novo acute myeloid leukemia patients. Eur J Haematol. 2018 Jul;101(1):86-94 [Pubmed]
  • Kuo WH, Chen YH, Tsai CH, Liao XW, Kuo SH, Tang JL. Outcome of acute leukemia patients with central nervous system (CNS) involvement treated with total body or CNS irradiation before transplantation. Therapeutic Radiology and Oncology. 2018 July. [Website]
  • Lin ME, Hou HA, Tsai CH, Wu SJ, Kuo YY, Tseng MH, Liu MC, Liu CW, Chou WC, Chen CY, Tang JL, Yao M, Li CC, Huang SY, Ko BS, Hsu SC, Lin CT, Tien HF. Dynamics of DNMT3A mutation and prognostic relevance in patients with primary myelodysplastic syndrome. Clin Epigenetics. 2018 Apr 2;10:42 [Pubmed]
  • Hou HA, Tsai CH, Lin CC, Chou WC, Kuo YY, Liu CY, Tseng MH, Peng YL, Liu MC, Liu CW, Liao XW, Lin LI, Yao M, Tang JL, Tien HF. Incorporation of mutations in five genes in the revised International Prognostic Scoring System can improve risk stratification in the patients with myelodysplastic syndrome. Blood Cancer J. 2018 Apr 4;8(4):39 [Pubmed]

2017

  • Tsai CH, Hou HA, Tang JL, Kuo YY, Chiu YC, Lin CC, Liu CY, Tseng MH, Lin TY, Liu MC, Liu CW, Lin LI, Yao M, Li CC, Huang SY1, Ko BS, Hsu SC, Lin CT, Wu SJ, Chen CY, Tsay W, Chuang EY, Chou WC, Tien HF. Prognostic impacts and dynamic changes of cohesin complex gene mutations in de novo acute myeloid leukemia. Blood Cancer J. 2017 Dec 29;7(12):663 [Pubmed]
  • Hou HA, Lu JW, Lin TY, Tsai CH, Chou WC, Lin CC, Kuo YY, Liu CY, Tseng MH, Chiang YC, Peng YL, Tang JL, Gong ZY, Lin LI, Tien HF. Clinico-Biological Significance of Suppressor of cytokine signaling 1 (SOCS1) Expression in Acute Myeloid Leukemia. Blood Cancer J. 2017 Jul 28;7(7):e588 [Pubmed]

2016

  • Chiang Y, Tsai CH (co-first author), Kuo SH, Yao M, Li CC, Huang SY, Ko BS, Lin CT, Hou HA, Chou WC, Liu JH, Lin CC, Wu SJ, Hsu SC, Chen YC, Lin KH, Lin DT, Tien HF, Tang JL, Chen YH. Reduced incidence of interstitial pneumonitis after allogeneic hematopoietic stem cell transplantation using a modified technique of total body irradiation. Scientific Reports. 2016 Nov 10;6:36730 [Pubmed]
  • Tsai CH, Hou HA, Tang JL, Liu CY, Lin CC, Chou WC, Tseng MH, Chiang YC, Kuo YY, Liu MC, Liu CW, Lin LI, Tsay W, Yao M, Li CC, Huang SY, Ko BS, Hsu SC, Chen CY, Lin CT, Wu SJ, Tien HF. Genetic alterations and their clinical implications in older patients with acute myeloid leukemia. Leukemia. 2016 Jul;30(7):1485-92 [Pubmed]
  • Hou HA, Liu CY, Kuo YY, Chou WC, Tsai CH, Lin CC, Lin LI, Tseng MH, Chiang YC, Liu MC, Liu CW, Tang JL, Yao M, Li CC, Huang SY, Ko BS, Hsu SC, Chen CY, Lin CT, Wu SJ, Tsay W, Tien HF. Splicing factor mutations predict poor prognosis in patients with de novo acute myeloid leukemia. Oncotarget. 2016 Feb 23;7(8):9084-101 [Pubmed]